Summarize the difference between “drug likeness” and “lead likeness”. Provide one example of a compound that fulfills the drug likeness criterion but is not a good lead (you must judge your answer, if there is a reference, you must include it)
2. Define “efficacy” of drugs. Indicate the reasons that make the drug have great difference between “efficacy” and “activity”.
3. Summarize why FDA uses 80%-125% AUC and Cmax fitness to judge the bioequivalence of generic drugs to brand name drugs. What is the difference between “generic drugs” and “me too drugs”?
