-Overall, the introduction should briefly establish the importance of the topic and connect the condition with the intervention at a general level (answering the question why would researchers be interested in vitamin D as a potential therapy for RA? Presenting the evidence that establishes the potentially therapeutic mechanisms of action for vitamin D in RA. This subtopic will answer the question “how does the molecular/cellular action of vitamin D connect with the molecular/cellular causes of RA?”
-The next step in your discussion will be to evaluate and describe the clinical evidence in humans for vitamin D in RA. This subtopic will answer the questions “how well does vitamin D work as a therapy in humans with RA?” and “what differences in RA clinical outcomes are observed when vitamin D is given as a therapy?”. Included will be your evaluation of the quality and meaning of the evidence, along with important facts like study design, population studied, dose, and quantitative outcomes (including magnitude of effect and statistical significance).
-Present relevant epidemiological evidence (if available) to establish the relationship between vitamin D intake/levels and RA incidence/prevalence/severity before moving into your conclusion section.
