fundamentals of nutrition, drugs and metabolism
Case Study : Mary
Age: 26 years old
Ethnicity: White British
Height (m2) = 165 cm
Weight (kg) = 65.6 kg
Waist measurement (cm) = 90 cm
Hip measurement (cm) = 100cm
Skinfold assessment % body fat
Triceps
1. 14.5
2. 15.5
3. 15.0 Mean mm
Biceps
1. 7.5
2. 8.0
3. 8.0 Mean mm
Subscapular
1. 8.5
2. 8.0
3. 8.0 Mean mm
Supra-iliac
1. 6.5
2. 5.5
3. 5.0 Mean mm
Total =
Log Total (X) =
Body Density: Females Equation
Body Density = 1.1581 – (0.0720*X)
Siri Equation % Body Fat
% Body fat = [(495/Body density) – 450]
Question 1:
Calculate Mary’s BMI and state what category according to ‘Quetelet’s index’ Mary’s falls into (5 marks)
Question 2:
Calculate Mary’s waist to hip ratio and briefly discuss what this ratio suggests with regard to fat distribution (5 marks).
Question 3:
Calculate the mean total for the four skinfold sites and work out the Log Total (X). Show your workings out and the appropriate units (5 marks).
Question 4:
Using the body density equation for females calculate Mary’s body density and then from the body density value obtained, please calculate her percentage body fat (indicated by skinfold measurements) using the Siri equation (5 marks).
Question 5:
(a) Calculate Mary’s predicted percentage body fat using her BMI measurement (show your workings out). (2 marks)
(b) Briefly compare Mary’s predicted percentage body fat using her BMI value and the percentage body fat value obtained (indicated by skinfold measurements) using the SIRI equation and a brief explain how the difference between the two values may have occurred (3 marks).
Section 1 End
Element 011 – Section 2 of 3
Section 2: Drugs and Medicine Data Handling Task
Table 1: List of compounds, their nature and their pka values.
Compound name Nature pKa
Ascorbic acid Weak acid 4.0
Phenol Weak acid 10
Sodium bicarbonate Weak base 10.5
2-naphthalammonium Weak base 4.5
Question 1- Describe the ionisation of the compounds in table 1 at pH values of: 3,6 and 12. (7.5 marks)
Question 2- Based on your knowledge on pKa, pH and ionisation describe a method whereby you can separate a solution containing: Sodium bicarbonate and ascorbic acid. (5 marks)
Question 3- Pharmaceutical Calculations.
A. If you know that sodium bicarbonate has a solubility of 8.4 g in 100g at 18 °C
I. Calculate (a) the molarity and (b) the molality of 8.4 g of Sodium bicarbonate in water. (2.5 marks)
II. if you had 200 mls of water, what is the minimum amount of Sodium bicarbonate that you will require to achieve supersaturation? (2.5 marks)
III. If 150 mls of a stock solution of sodium bicarbonate having a concentration of 0.5 M was diluted to 300 mls. What will be the final concentration of the diluted solution? (2.5 marks)
B. If the total amount of a surfactants to be used in an emulsion is 5 g, calculate the amount of Span 80 (HLB= 4.3) and Tween 20 (HLB= 16.7) needed in order to obtain an HLB value of 10.5.
