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What are the anatomical, physiological, pathological, or epidemiological issues? Which body systems are affected?

What are the anatomical, physiological, pathological, or epidemiological issues?
Which body systems are affected?
What happens at the cellular or genetic level?
Which chemical or biological issues are most important?

MATHEMATICAL/ANALYTICAL Perspective of Inquiry

What are the economic issues involved?
Which economic theories or approaches best explain the issue?
What are the statistical facts related to the issue?
Which statistical processes used to study the issue provide for the best explanation or understanding?

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