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Describe the role of adenomatous polyposis coli (APC) gene mutation in the progression of colorectal cancer.

Presentation: A 68-year-old male, with no previous history of bowel cancer presents with symptoms of abdominal bloating, fatigue and weight loss. Investigation: Colonoscopy, biopsy, MRI and genetic screening identify that the tumour has spread to other sites within the body (staging example provided in the figure below). Genetic testing reveals that there are mismatch repair […]

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